DIS Central was the centre of operations for the DIS. Like its successor, only the main room, the prison wing, and the department head's office were shown, but it was presumably larger. The DIS's control centre was shown on a few occasions as well, most notably during their war with the rest of the PPC. Individual Guards are known to have had their own rooms in Central.

During the events of the Reorganisation, Blue Photon was imprisoned here, and Nyx Nightingale forced into joining the DIS within DIS Central.

After the Reorganisation, it was dismantled, to make way for the Tomb of the Unknown PPC Agent.