- Tawaki Penguin joins the DMS and is partnered with Nicholas Duval.
- Tadkeeta is recruited from a Narnia badfic by Agents Suicide and Diocletian.
- The Les Misérables Songfic Crisis takes place.
- Final Fantasy XII is released for the PlayStation 2.
- Launch of the 2006-2007 run of the Multiverse Monitor.
- The events of the PPC Computer Game take place around this time, but the ending of the game retroactively prevents most of them.
- Ōkami is released in Japan and North America for the PlayStation 2.
- Agent Tasmin Haynes is partnered with Agent Allison Carter in the Sub-department of Rare Fandoms.
- Agent Alanna Bailey retires.
- Branwen Beaton is recruited and partnered with Agent Sophia Cole.
- The West Wing completes its seven-season run on NBC.
- The Black Cats cut the power in HQ by piling large amounts of canon material around the grave of J.R.R. Tolkien, paving the way for their invasion.
- The reincarnated Elanor Laison returns to HQ.
- The Department of WTF is launched with the Snowthorn as its head and Elanor Laison and Mortic Wentway as its first agents.
- Agent Tadkeeta experiences six years on the Hyperaccelerated Planet.
- The mission to Legendary Badfic "Celebrian" takes place. Agent Ithalond is recruited by Agents Dafydd Illian and Constance Sims.
- Death and resurrection of Agent Dafydd Illian.
- Agents Dafydd Illian and Constance Sims retire.
- Agent Selene Windflower is partnered with Agent Narto Telyan.
- The events of Crashing Down take place:
- Nearly all of the Black Cats, the Mysterious Somebody and his army, the Bindweed, the Orchid and many PPC agents and staff (including the Wisteria, India, much of the DIA and DAVD, technically Vemi Fincaran, and Blue Photon) are killed. Morgan regenerates.
- In the aftermath of the Cats' invasion, Dassie Hyrax, Nyx Nightingale, Tango Dioxide, Ontic Laison, the Nightshade and the Gladiolus rejoin the PPC.
- Following the death of the Wisteria, the Board of Department Heads is reshuffled. Doctor Fitzgerald replaces the Wisteria and the Floating Hyacinth replaces the Lichen.
- During the rebuilding of DIA Central, the Tiger Lily promotes Basilico Andretti to a position as one of her lieutenants, alongside Dúros Black. Reorganisation of the DIA begins shortly after.
- The FGenMS01 facility is destroyed, and in the resulting power vacuum the Yarrow eventually takes over/establishes the League of Mary Sue Factories.
- Pirates of the Caribbean: Dead Man's Chest is released in the US. The fanfic surge continues.
- Fanfic Land opens for the first time.
- A retirement party for Dafydd Illian and Constance Sims is held in HQ.
- Dafydd Illian and Constance Sims marry.
- Agent Tawaki Penguin transfers to the Department of Floaters and is partnered with Agent Iskillion-Galuit-Elendil.
- Agent Nicholas Duval marries Agent Kamkenta Squee.
- The events of "The Scourge of the Scarlet Maiden" take place, including the release of a grizzly bear into the Cafeteria.
- Stormsong and Skyfire are recruited by Agents Laburnum and Foxglove.
- Ilraen-Aroline-Fothergill is recruited by Agents Twiggy and Brittany. He stays in FicPsych for two-three weeks.
- The final Series of Unfortunate Events novel, The End, is published.
- The English dub of Inuyasha concludes its run on Cartoon Network. A classic era of fangirling begins to wind down.
- The presumed death of Agent Adam Zvi occurs.
- The Legend of Zelda: Twilight Princess is originally released in North America for the Wii, coinciding with the release of the Wii itself.
- Tasmin Haynes becomes guardian to Trent.
- Agent Zed transfers to the DBS.
- Agent Supernumerary is officially transferred to the DIC and partnered with Ilraen. Their first mission takes place at this time.
- Tawaki publishes "Dragon Surprise" in his LiveJournal; the events of the mission take place. The events of the Assimilation Crisis occur shortly thereafter:
- Agent Tawaki Penguin and Intern Hul Choka are assimilated by the Borg.
- Agent Tadkeeta spreads the word and rounds up a team to rescue the agents and neuralyze the Borg Cube.
- During the effort, six more agents are assimilated (Aldion, Hydro, Stoneship Tayrime, Gareth, Behnashiren, and Nathonea Dewstan), and two are killed (Salok and Andronicus).
- Agent Narto Telyan's two timelines merge.
- Jarre Jarre Hastursen snaps, killing nine canon characters and herself in a Ten Little Indians reenactment.
- Dawn McKenna joins the PPC and is placed in the DMS.
- The PPC Holiday Filk Game definitely happens.
- Early in the year:
- The Chicago 2006 PPC Gathering takes place. Neshomeh, Tungsten Monk, and Cedar Copse attend.
- The failed mission to Legendary Badfic "Subjugation" takes place. Agents Cameo, Suicide, Diocletian, Gunny MacDougal, Wayne Garamond, Rez Montrose, and Flip Finley all go MIA; only Agent Supernumerary returns directly to Headquarters.
- Tanfin Illian travels back in time from 2030, is nearly killed by the Black Cats, and bumps into Jay Thorntree and Acacia Byrd.
- Tadkeeta transfers to DOGA and is partnered with Agent T'Zar.
- Agent Trojanhorse spends much of this year in hiding.
- Wobbles the Clown is recruited
- The first few missions to That Series take place.
- KF and MFPC are created.